Set up your ANSYS structural analysis as usual. Just remember to put a Fluid-Solid interface on the solid surface that meets the fluid. You can go ahead and run and save your analysis.
In CFX, you can set up a transient simulation with external coupling to ANSYS. You will specify that
CFX will receive Total Mesh Displacement from ANSYS but will pass it back nothing.
You need only run a time step or two.
Under Solver Control, you will specify for ANSYS to solve first.
Once its all set up, run the problem. The deformed mesh will be present in the CFX results file. You can import the mesh from this results file into a new session of CFX-Pre so that the deformed mesh will now be available for a new CFD simulation.